Reduction of Palmitoyl Dihydroxyacetone Phosphate by Mitochondria
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چکیده
منابع مشابه
Enzymatic reduction of alkyl and acyl derivatives of dihydroxyacetone phosphate by reduced pyridine nucleotides.
The reductions of either acyl or alkyl derivatives of dihydroxyacetone phosphate by enzymes from ascites tumor cell microsomes with NADPH were studied. The reaction rate was measured by determining the formation of labeled lipid from [4-3H]NADPH. The products were characterized as either 1-acyl or 1-alkyl [2-3H]glycerol d-phosphate formed from the corresponding keto derivatives. The enzymes wer...
متن کاملExclusive localization in peroxisomes of dihydroxyacetone phosphate acyltransferase and alkyl-dihydroxyacetone phosphate synthase in rat liver.
Dihydroxyacetone phosphate acyl transferase (DHAP-AT), alkyl dihydroxyacetone phosphate synthase (alkyl-DHAP-synthase), and glycerol-3-phosphate acyltransferase (GPAT) activities were investigated under optimal assay conditions using highly purified organelle preparations. The data presented clearly indicate that GPAT activity was mainly localized in mitochondria and microsomes, whereas DHAP-AT...
متن کاملInhibition of glucose 6-phosphate dehydrogenase by palmitoyl coenzyme A.
Low concentrations of palmitoyl coenzyme A inhibit yeast glucose-6-P dehydrogenase (TAKETA, K., AND POGELL, B. M. (1966) J. Biol. Chem. 241, 720). This inhibition is prevented or reversed by bovine serum albumin, mycobacterial polysaccharides, or alkylated cyclodextrins. Sephadex chromatography and sucrose density gradient centrifugation show that palmitoyl-CoA inhibits by dissociating the tetr...
متن کاملAcyl dihydroxyacetone phosphate: precursor of alkyl ethers.
1-0-Alkyl dihydroxyacetone phosphate is biosynthesised in guinea pig liver mitochondria and in rat brain microsomes by direct reaction of a long chain alcohol and acyl dihydroxyacetone phosphate. ATP and Mg* are stimulatory but coenzyme A is not necessary for the reaction. 1-0-Alkyl dihydroxyacetone phosphate (alkyl DHAP)l was shown to be biosynthesized from long chain alcohol and DHAP with ATP...
متن کاملInhibition of Glucose 6-Phosphate Dehydrogenase by Palmitoyl Coenzyme A*
Low concentrations of palmitoyl coenzyme A inhibit yeast glucose-6-P dehydrogenase (TAKETA, K., AND POGELL, B. M. (1966) J. Biol. Chem. 241, 720). This inhibition is prevented or reversed by bovine serum albumin, mycobacterial polysaccharides, or alkylated cyclodextrins. Sephadex chromatography and sucrose density gradient centrifugation show that palmitoyl-CoA inhibits by dissociating the tetr...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1968
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)93342-9